KMID : 0988720060220030261
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Journal of the Korean Academy of Stomatognathic Function and occlusion 2006 Volume.22 No. 3 p.261 ~ p.270
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Effect of Blasted or Anodized Titanium Surface Roughness on Adhesion and Differentiation of Osteoblasts
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Park Chan-Jin
Cho Lee-Ra Ko Sung-Hee Um Heung-Sik Chang Beom-Seok
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Abstract
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Effect of Blasted or Anodized Titanium Surface Roughness on Adhesion and Differentiation of Osteoblasts Chan-Jin Park*, Lee-Ra Cho*, Yang-Jin Yi*, Sung-Hee Ko** *Department of Prosthodontics, **Department of Pharmacology College of Dentistry, Kangnung National University and Oral Science Institute The success of an implant is determined by its integration into the tissue surrounding the biomaterial. Surface roughness is considered to influence the behavior of adherent cells. The aim of this in vitro study was to determine the effect of surface roughness on Saos-2 osteoblast-like cells. Titanium disks, blasted with 75 § aluminum oxide particles and anodic oxidized and machined titanium disks were prepared. Saos-2 were plated on the disks at a density of 50,000 cells per well in 48-well dishes. After 1 hour, 1 day, 6 days cell numbers were counted. One day, 6 days after plating, alkaline phosphatase(ALPase) activity was determined. Compared to experimental groups, the number of cells was significantly higher on control group. The stimulatory effect of surface roughness on ALPase was more pronounced on the experimental groups than on control group. These results demonstrate that surface roughness alters proliferation and differentiation of osteoblasts. The results also suggest that implant surface roughness may play a role in determining phenotypic expression of cells.
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KEYWORD
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surface roughness, blasted, anodic oxidized, osteoblast-like cell
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